PIRCHE In Lung Transplantation

Some exciting publication news today! The PIRCHE-II score was shown to be a superior overall predictor of dnDSA than HLAMatchmaker in lung transplantation.

Andrew Lobashevsky et. al have recently published a brand new article in the Journal Clinical Transplantation.

In a cohort of 220 lung transplant recipients, the PIRCHE-II and HLAMatchmaker algorithms were used to analyze the epitope loads of the cohort’s mismatched HLAs. The results of this retrospective study show that:

• The percentage of patients that developed de novo donor-specific antibodies (dnDSA – a key determinant of graft survival in solid organ transplantation) was significantly higher in the transplant recipient group with a mismatching score above a detected threshold than in transplant recipient group with a mismatching score below this same threshold.
• The PIRCHE-II score was shown to be a superior overall predictor of dnDSA than HLAMatchmaker
• The PIRCHE-II score was also shown to be useful in the prediction of separate dnDSA1 and dnDSA2 formation.

It’s always rewarding for us to see the PIRCHE literature grow and to be able to present more evidence of PIRCHE’s effectiveness in improving transplantation outcomes for patients. A link to the full piece is available Here — congratulations to everyone involved in this article’s publication and we hope that you enjoy reading it!

The PIRCHE Team

‍