Digital Products
platform
THe TxPREDICTOR DIFFERENCE
TxPredictor
Competitor 1
Competitor 2
Competitor 3
T Cell Matching
B Cell Matching
Real time calculations
Cloud based
Extensive clinical validation
Easy to use platform
Low resolution typing support
Quality controlled
MODULES
Single Patient Matching
Stem Cell & SOT
The Single Patient Matching module is available for both stem cell transplantation (SCT) and solid organ transplantation (SOT). It allows you to match multiple donors with your patient and to compare the results. The result table can be filtered quickly and sorted however you like. If you want to dive deep into the data, check out the interactive heatmap and peptide tables for every single match.
The color-code in the heatmap indicates which HLA mismatches strongly contribute to the PIRCHE score of a particular HLA presenter.
Search Profile
Stem CelL
The SCT Search Profile helps identify low-epitope-mismatched HLA mismatches and estimate the likelihood of finding a donor with a low PIRCHE score, even without direct access to a stem cell donor registry. It features a combined chart and table view for quickly locating preferable HLA mismatches.
Risk and Acceptable Mismatch Profile
SOLID ORGAN TRANSPLANT
The SOT Risk and Acceptable Mismatch Profile allows you to evaluate the contribution of individual mismatches to the overall PIRCHE score and to match an entire donor population to your patient to estimate average PIRCHE scores.
Combining these features, RAMP helps interactively assess acceptable mismatches and their impact on donor frequency. The Risk Profile's histogram visualizes donor frequency by PIRCHE score, indicating better chances of finding a well-matched donor with higher frequencies of low PIRCHE scores.
T-Cell Memory
SOLID ORGAN TRANSPLANT
The T cell memory (Tmem) update to the RAMP module distinguishes between "unacceptable mismatches" and "previous immunizers", using the latter as a reference peptide set to compare against common alleles. Overlaps may indicate previous T cell responses, suggesting that certain donor/recipient combinations should be avoided to prevent re-exposure.
The impact spans across loci, meaning selecting an HLA-B as a previous immunizer could highlight many overlapping A alleles. This adds a crucial dimension of analysis for identifying the best possible transplant matches.
INTEGRATIONS WITH PIRCHE
LIMS integration with Histotrac
Pirche has partnered with HistoTrac LMS Software to provide a streamlined and seamless integration for obtaining PIRCHE scores and optimizing automated non-PHI data exchange directly between the HistoTrac LMS Software and TxPREDICTOR.
MatchX integration with Werfen
Werfen (formally Immucor) and Pirche have partnered to provide customers with next-generation antibody analysis utilizing epitope scoring. The MatchX API solution involves integrating Pirche’s advanced epitope matching technology with Werfen's comprehensive suite of transfusion and transplantation diagnostic solutions.
PIRCHE HLA Interface
If the Histotrac and MatchX API solutions do not meet your needs, we are here to support customized workflows. These tailored APIs ensure smooth data exchange and enhance the efficiency of compatibility assessments by automating the data exchange process.
