PUBLISHED BY
Sakamoto, Shintaro; Iwasaki, Kenta; Tomosugi, Toshihide; Niemann, Matthias; Spierings, Eric; Miwa, Yuko; Horimi, Kosei; Takeda, Asami; Goto, Norihiko; Narumi, Shunji; Watarai, Yoshihiko; Kobayashi, Takaaki
PUBLISHED IN
Frontiers in Immunology
PATIENTS
691
ABSTRACT
HIGHLIGHTS
- Study aims to elucidate the association of eplet mismatches and predicted indirectly recognizable HLA epitopes (PIRCHE) scores with de novo DSA production.
- Weak correlation between eplet mismatches and PIRCHE scores was identified, although both measurements were associated with classical HLA mismatches. Class II (DRB+DQB) eplet mismatches were significantly correlated with the incidence of de novo class II (DR/DQ) DSA production.
- PIRCHE scores were also significantly correlated with de novo class II DSA production .
- Patients with low levels of both class II eplet mismatches and PIRCHE scores developed de novo class II DSA only in 4/179 (2.2%).
- The study concludes that the analysis of T cell and B cell epitopes can provide beneficial information on the design of individualized immunosuppression regimens for prevention of de novo DSA production after kidney transplantation.
